The FDA initially regulated BVO as a food additive in 1970 due to toxicity concerns. They removed it from the Generally Recognized as Safe (GRAS) list and began overseeing its use under food additive regulations while conducting safety studies13. This action was taken after questions about BVO's safety were raised in the late 1960s.
The FDA revoked BVO's food use authorization due to studies showing potential adverse health effects on humans. Conducted in collaboration with the National Institutes of Health, the study demonstrated damaging effects on the thyroid in rats and analyzed the tissue distribution of the main metabolites1.
The FDA's revocation of BVO in food items will take effect on August 2. This decision comes after studies conducted in collaboration with the National Institutes of Health found potential adverse effects in humans1. BVO, a chemical ingredient containing bromine, has been used in small quantities in some citrus-flavored drinks to keep the flavor evenly distributed.