
Google's StylEx framework aims to address the challenges in the field of medical imaging related to the lack of explainability in AI models. Current methods for explaining AI models in medical imaging often rely on techniques that generate heatmaps indicating the importance of different pixels in an image. However, these methods fall short of explaining the "what" and "why" behind these features, particularly higher-level characteristics like texture, shape, or size that might underlie the model's decisions. StylEx leverages a StyleGAN-based image generator guided by a classifier to identify and visualize visual signals correlated with a classifier's predictions, providing a deeper understanding of the model's decisions and enhancing explainability.

Current methods for explaining AI decisions in medical imaging often rely on techniques that generate heatmaps indicating the importance of different pixels in an image. These methods highlight the regions of an image that contribute the most to the AI model's decision. However, they have certain limitations:
They primarily focus on the "where" of important features, but they don't explain the "what" and "why" behind these features. In other words, they don't typically explain higher-level characteristics like texture, shape, or size that might underlie the model's decisions.
They may not be able to capture complex patterns or features that are not easily discernible to the human eye. This is particularly true for deep learning models, which can learn intricate patterns in the data but are often seen as "black boxes" due to their complexity.
They may not provide a clear understanding of how specific visual changes affect the AI model's decisions. This lack of explainability can make it difficult for medical professionals to trust and use these models in clinical practice.
They may not be able to identify or explain the potential biases in the data or the model. This is particularly important in medical imaging, where biases can lead to incorrect diagnoses or treatments.
Google's StylEx framework aims to overcome these limitations by leveraging a StyleGAN-based image generator guided by a classifier. This approach generates counterfactual visualizations that show how changes in specific visual attributes affect the model's predictions. An interdisciplinary panel of experts then reviews these visualizations to formulate hypotheses for future research.

The StylEx framework enhances the explainability of AI models in medical imaging by providing a deeper understanding of the visual attributes that affect the models' decisions. It leverages a StyleGAN-based image generator guided by a classifier to generate counterfactual images and visualize the attributes that influence classifier predictions.
This approach goes beyond existing methods that rely on heatmaps indicating the importance of different pixels in an image. Instead, StylEx focuses on higher-level characteristics like texture, shape, or size that might underlie the model's decisions.
The StylEx workflow involves four key steps:
By involving an interdisciplinary panel of experts, including clinicians, social scientists, and machine learning engineers, the framework ensures that the insights are rigorously interpreted, accounting for potential biases and suggesting new avenues for scientific inquiry. This holistic approach allows for the consideration of both biological and socio-cultural determinants of health.
Overall, the StylEx framework provides a more comprehensive understanding of AI models' decision-making process in medical imaging, enabling the formulation of new hypotheses and potentially uncovering novel scientific insights from the data.